Antitumor efficacy of biosynthesized manganese nanoparticles

Abuheiba, Eman; M. El-Sonbaty, Sawsan; Abdel-Samed, Nahed; Kandil, Eman

doi:10.21608/nrmj.2019.37212

Antitumor efficacy of biosynthesized manganese nanoparticles

Document Type : Original Article

Authors

¹ Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

² Radiation Microbiology Department, National Center for Radiation Research and Technology; Egyptian Atomic Energy Authority, Cairo, Egypt

³ Physiology Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt

10.21608/nrmj.2019.37212

Abstract

This study aimed to evaluate the in vitro and in vivo antitumor potential of manganese nanoparticles, in management of hepatocellular carcinoma (HCC) induced in rats. Manganese nanoparticles were biosynthesized using Lactobacillus helveticus cells. In vitro study of manganese nanoparticles on HepG-2 (human cell line of a well-differentiated HCC) revealed an IC₅₀ of 21.5 mM. The in vivo efficacy of manganese nanoparticles was evaluated by measuring the antioxidant activities against oxidative stress caused by diethylnitrosamine (DEN) in rates liver tissues. This treatment significantly improved the alanine aminotransferase (ALT) activity and total protein compared to DEN group. Results showed that manganese nanoparticles were effective in treatment of HCC induced by diethylnitrosamine (DEN) in rats. So manganese nanoparticles can serve as a good therapeutic agent for the treatment of hepatocellular carcinoma, and deserve further studies in the future.

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