Antitumor efficacy of biosynthesized manganese nanoparticles

Document Type : Original Article


1 Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

2 Radiation Microbiology Department, National Center for Radiation Research and Technology; Egyptian Atomic Energy Authority, Cairo, Egypt

3 Physiology Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt


This study aimed to evaluate the in vitro and in vivo antitumor potential of manganese nanoparticles, in management of hepatocellular carcinoma (HCC) induced in rats. Manganese nanoparticles were biosynthesized using Lactobacillus helveticus cells.  In vitro study of manganese nanoparticles on HepG-2 (human cell line of a well-differentiated HCC) revealed an IC50 of 21.5 mM.  The in vivo efficacy of manganese nanoparticles was evaluated by measuring the antioxidant activities against oxidative stress caused by diethylnitrosamine (DEN) in rates liver tissues. This treatment significantly improved  the alanine aminotransferase (ALT) activity  and  total protein compared to DEN group. Results showed that manganese nanoparticles were effective in treatment of HCC induced by diethylnitrosamine (DEN) in rats. So manganese nanoparticles can serve as a good therapeutic agent for the treatment of hepatocellular carcinoma, and deserve further studies in the future.


Volume 3, Issue 3
May and June 2019
Pages 387-395
  • Receive Date: 18 June 2019
  • Revise Date: 22 June 2019
  • Accept Date: 24 June 2019
  • First Publish Date: 24 June 2019